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Journal of Biomedical Optics

Optical coherence tomography of malignancy in hamster cheek pouches
Author(s): Erin S. Matheny; Nevine M. Hanna; Reza Mina-Araghi; Woong Gyu Jung; Zhongping Chen; Petra B. B. Wilder-Smith; Matthew Brenner
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Paper Abstract

Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-μm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis.

Paper Details

Date Published: 1 September 2004
PDF: 4 pages
J. Biomed. Opt. 9(5) doi: 10.1117/1.1783897
Published in: Journal of Biomedical Optics Volume 9, Issue 5
Show Author Affiliations
Erin S. Matheny, Univ. of California/Irvine (United States)
Nevine M. Hanna, Univ. of California/Irvine (United States)
Reza Mina-Araghi, Univ. of California/Irvine (United States)
Woong Gyu Jung, Univ. of California/Irvine (United States)
Zhongping Chen, Univ. of California/Irvine (United States)
Petra B. B. Wilder-Smith, Univ. of California/Irvine (United States)
Matthew Brenner, Univ. of California/Irvine (United States)

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