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Journal of Biomedical Optics

Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography
Author(s): Julian Moger; Stephen John Matcher; C. Peter Winlove; Angela C. Shore
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Paper Abstract

Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler amplitude optical coherence tomography (DAOCT), a novel extension of DOCT. Velocity profiles and concentration distributions of normal and rigidified in vitro red blood cell suspensions are shown to vary as functions of mean flow velocity, cell concentration, and cell rigidity. Deviation from the parabolic velocity profile expected for Pouseille flow is observed for both rigid and normal cells at low flow rates. Axial red cell migration both toward and away from the tube axis is observed for both rigid and normal cells as a function of flow velocity. Good agreement is found between our measurements, and theoretical expectations.

Paper Details

Date Published: 1 September 2004
PDF: 13 pages
J. Biomed. Opt. 9(5) doi: 10.1117/1.1781163
Published in: Journal of Biomedical Optics Volume 9, Issue 5
Show Author Affiliations
Julian Moger, Univ. of Exeter (United Kingdom)
Stephen John Matcher, Univ. of Exeter (United Kingdom)
C. Peter Winlove, Univ. of Exeter (United Kingdom)
Angela C. Shore, Univ. of Exeter (United Kingdom)


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