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Journal of Biomedical Optics

New fluorescence imaging probe with high spatial resolution for in vivo applications
Author(s): Vincent Bonnans; Tijani Gharbi; Christian Pieralli; B. F. M. Wacogne; Ph. Humbert
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Paper Abstract

A new fiberized fluorescence imaging probe is presented. This device can potentially be used for a wide range of biological or medical applications. By exploiting the chromatic aberrations of gradient index lenses, the excitation blue or near-UV excitation light is focused on the sample surface, while the red fluorescence signal is efficiently launched back to collecting fibers. The excitation fiber is single mode at the working wavelength so that a resolution of 5 µm is obtained over a scanning area of several square millimeters. Experimental fluorescence images are presented. They concern either self-fabricated fluorescent microsamples or views of leaves that constitute an example of biological tissues analysis. The probe can also be adapted for spectroscopic investigations

Paper Details

Date Published: 1 September 2004
PDF: 6 pages
J. Biomed. Opt. 9(5) doi: 10.1117/1.1781162
Published in: Journal of Biomedical Optics Volume 9, Issue 5
Show Author Affiliations
Vincent Bonnans, Univ. de Franche-Comte (France)
Tijani Gharbi, Univ. de Franche-Comté (France)
Christian Pieralli, Univ. de Franche-Comte (France)
B. F. M. Wacogne, Univ. de Franche-Comte (France)
Ph. Humbert, UFR Medecine-Pharmacie (France)


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