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Journal of Biomedical Optics

Changes in regional cerebral blood volume in frontal cortex during mental work with and without caffeine intake: functional monitoring using near-infrared spectroscopy
Author(s): Terumasa Higashi; Yukari Sone; Kanta Ogawa; Yuri T. Kitamura; Kayoko Saiki; Setsuko Sagawa; Toshio Yanagida; Akitoshi Seiyama
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Paper Abstract

Near-infrared spectroscopy (NIRS) was used to measure frontal regional cerebral blood volume (rCBV) in a person whose brain was under the influence of pharmacological agents while the person was performing a complex task. Fourteen healthy participants were administered Uchida-Kraepelin psychodiagnostic (UKP) tests before and after caffeine intake, and the concentration of caffeine in the urine was measured. The average number of answers and the average number of correct answers given by the participants improved significantly following caffeine intake. During the UKP testing, changes in the rCBV in the inferior frontal cortex were continuously measured using NIRS. The volume during the rest periods decreased as a result of caffeine-induced constriction of the cerebral arteriola. The volume increased during the mental work, but the degree of the increase was the same before and after caffeine intake. Although the performance of the mental work improved following caffeine intake, the improvement was not reflected in the rCBV in the inferior frontal cerebral cortex. These results suggest that caffeine helps to protect the brain from excessive hyperemia in addition to activating the neurons in the prefrontal cortex.

Paper Details

Date Published: 1 July 2004
PDF: 6 pages
J. Biomed. Opt. 9(4) doi: 10.1117/1.1755233
Published in: Journal of Biomedical Optics Volume 9, Issue 4
Show Author Affiliations
Terumasa Higashi, Osaka Univ. (Japan)
Yukari Sone, Osaka Univ. (Japan)
Kanta Ogawa, Osaka Univ. (Japan)
Yuri T. Kitamura, Osaka Univ. (Japan)
Kayoko Saiki, Kobe Pharmaceutical Univ. (Japan)
Setsuko Sagawa, Osaka Univ. (Japan)
Toshio Yanagida, Osaka Univ. (Japan)
Akitoshi Seiyama, Osaka Univ. (Japan)

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