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Journal of Biomedical Optics • Open Access

Spectroscopic detection of bladder cancer using near-infrared imaging techniques
Author(s): Stavros G. Demos; Regina Gandour-Edwards; Rajen Ramsamooj; Ralph de Vere White

Paper Abstract

High-contrast imaging of bladder cancer is demonstrated using near-infrared autofluorescence under long-wavelength laser excitation in combination with cross-polarized elastic light scattering. Fresh unprocessed surgical specimens obtained following cystectomy or transurethral resection were utilized and a set of images for each tissue sample was recorded. These images were compared with the histopathology of the tissue sample. The experimental results indicate that the intensity of the near-infrared emission as well as that of the cross-polarized backscattered light was considerably different in cancer tissues than in that of the contiguous nonneoplastic tissues, allowing an accurate delineation of a tumor's margins.

Paper Details

Date Published: 1 July 2004
PDF: -55 pages
J. Biomed. Opt. 9(4) doi: 10.1117/1.1753587
Published in: Journal of Biomedical Optics Volume 9, Issue 4
Show Author Affiliations
Stavros G. Demos, Lawrence Livermore National Lab. (United States)
Regina Gandour-Edwards, Univ. of California/Davis (United States)
Rajen Ramsamooj, Univ. of California/Davis (United States)
Ralph de Vere White, Univ. of California/Davis (United States)

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