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Journal of Biomedical Optics

Portable near-infrared diffusive light imager for breast cancer detection
Author(s): Nanguang Chen; Minming Huang; Hongjun Xia; Daqing Piao; Edward Cronin; Quing Zhu
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Paper Abstract

We present a frequency-domain near-infrared optical tomography system designed for breast cancer detection, in conjunction with conventional ultrasound. It features fast optical switching, three-wavelength excitations, and avalanche photodiode as detectors. Laser diodes at 660, 780, and 830 nm are used as light sources and their outputs are distributed sequentially to one of nine source fibers. An equivalent 130-dB isolation between electrical signals from different source channels is achieved with the optical switches of very low crosstalk. Ten detection channels, each of which includes a silicon avalanche photodiode, detect diffusive photon density waves simultaneously. The dynamic range of an avalanche photodiode is about 20 to 30 dB higher than that of a photomultiplier tube, thus eliminating the need for multistep system gain control. The entire system is compact in size (<0.051 m3) and fast in data acquisition (less than 2 sec for a complete scan). Calibration and the clinical experiment results are presented in the paper.

Paper Details

Date Published: 1 May 2004
PDF: 7 pages
J. Biomed. Opt. 9(3) doi: 10.1117/1.1695410
Published in: Journal of Biomedical Optics Volume 9, Issue 3
Show Author Affiliations
Nanguang Chen, Univ. of Connecticut (United States)
Minming Huang, Univ. of Connecticut (United States)
Hongjun Xia, Univ. of Connecticut (United States)
Daqing Piao, Univ. of Connecticut (United States)
Edward Cronin, Hartford Hospital (United States)
Quing Zhu, Univ. of Connecticut (United States)

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