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Journal of Biomedical Optics • Open Access

Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies
Author(s): Antonio Pifferi; Alessandro Torricelli; Paola Taroni; Andrea Li Bassi; Ekaterine Chikoidze; Eleonora Giambattistelli; Rinaldo Cubeddu

Paper Abstract

In vivo absorption and reduced scattering spectra of the human calcaneous from 650 to 1000 nm were assessed using a laboratory system for time-resolved transmittance spectroscopy. Measurements were performed on the calcaneous of seven female volunteers ranging from 26 to 82 years of age. The analysis of the absorption spectra, using a linear combination of the key tissue absorbers (bone mineral, water, lipids, oxy- and deoxyhemoglobin), revealed a general decrease in bone mineral content and an increase in lipids with age, which is in agreement with the aging transformations that occur in bone tissues. The scattering spectra were less effective in detecting such changes in older subjects, showing only a minor decrease in the coefficient for these subjects. The capability to noninvasively quantify bone tissue composition suggests a possible use of optical biopsy for the diagnosis of bone pathologies such as osteoporosis, which are characterized by a progressive reduction and transformation of the mineral in the bone matrix.

Paper Details

Date Published: 1 May 2004
PDF: 7 pages
J. Biomed. Opt. 9(3) doi: 10.1117/1.1691029
Published in: Journal of Biomedical Optics Volume 9, Issue 3
Show Author Affiliations
Antonio Pifferi, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Andrea Li Bassi, Politecnico di Milano (Italy)
Ekaterine Chikoidze, Politecnico di Milano (Italy)
Eleonora Giambattistelli, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)

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