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Journal of Biomedical Optics • Open Access

Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy
Author(s): Peter Snoer Jensen; Jimmy Bak; Soren Ladefoged; Stefan Andersson-Engels; Lennart Friis-Hansen

Paper Abstract

The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month. The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model.

Paper Details

Date Published: 1 May 2004
PDF: 5 pages
J. Biomed. Opt. 9(3) doi: 10.1117/1.1689337
Published in: Journal of Biomedical Optics Volume 9, Issue 3
Show Author Affiliations
Peter Snoer Jensen, Riso National Lab. (Denmark)
Jimmy Bak, Risoe National Lab. (Denmark)
Soren Ladefoged, Copenhagen Univ. Hospital (Denmark)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Lennart Friis-Hansen, Copenhagen Univ. Hospital (Denmark)

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