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Journal of Biomedical Optics

Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery
Author(s): Bernard Choi; Thomas E. Milner; Jeehyun Kim; Jared N. Goodman; Gracie Vargas; Guillermo Aguilar; John Stuart Nelson
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Paper Abstract

The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5–10 µm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, IntralipidTM, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.

Paper Details

Date Published: 1 March 2004
PDF: 5 pages
J. Biomed. Opt. 9(2) doi: 10.1117/1.1648647
Published in: Journal of Biomedical Optics Volume 9, Issue 2
Show Author Affiliations
Bernard Choi, Univ. of California/Irvine (United States)
Thomas E. Milner, Univ. of Texas/Austin (United States)
Jeehyun Kim, Univ. of Texas/Austin (United States)
Jared N. Goodman, Brigham Young Univ. (United States)
Gracie Vargas, Univ. of Texas Medical Branch (United States)
Guillermo Aguilar, Univ. of California/Irvine (United States)
John Stuart Nelson, Univ. of California/Irvine (United States)


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