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Journal of Biomedical Optics

Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis
Author(s): Sandrine Hocde; Olivier Loréal; Olivier Sire; Catherine Boussard-Pledel; Bruno Bureau; B. Turlin; Julie Keirsse; P. Leroyer; Jacques Lucas
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Paper Abstract

Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A strict control of the fiber diameter in the tapered sensing zone allows high sensitivity and wide spectral range exploration from 800 to 3000 cm–1. Then, merely in depositing the mouse liver biopsies on the fiber, this device has enable us to differentiate between tumorous and healthy tissues.

Paper Details

Date Published: 1 March 2004
PDF: 4 pages
J. Biomed. Opt. 9(2) doi: 10.1117/1.1646415
Published in: Journal of Biomedical Optics Volume 9, Issue 2
Show Author Affiliations
Sandrine Hocde, NP Photonics Inc. (United States)
Olivier Loréal, Univ. de Rennes 1 (France)
Olivier Sire, Univ. de Bretagne-Sud (France)
Catherine Boussard-Pledel, Univ. de Rennes 1 (France)
Bruno Bureau, Univ. de Rennes I (France)
B. Turlin, INSERM (France)
Julie Keirsse, Univ. de Rennes 1 (France)
P. Leroyer, INSERM (France)
Jacques Lucas, Univ. de Rennes I (France)


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