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Journal of Biomedical Optics

Determination of burn depth by polarization-sensitive optical coherence tomography
Author(s): Shyam M. Srinivas; Johannes F. de Boer; Boris Hyle Park; Kourosh Keikhanzadeh; Huai-En L. Huang; Jun Zhang; Woong Gyu Jung; Zhongping Chen; John Stuart Nelson
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Paper Abstract

An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 °C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/µm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients.

Paper Details

Date Published: 1 January 2004
PDF: 6 pages
J. Biomed. Opt. 9(1) doi: 10.1117/1.1629680
Published in: Journal of Biomedical Optics Volume 9, Issue 1
Show Author Affiliations
Shyam M. Srinivas, Univ. of California/Irvine (United States)
Johannes F. de Boer, Univ. of California/Irvine (United States)
Boris Hyle Park, Univ. of California/Irvine (United States)
Kourosh Keikhanzadeh, Univ. of California/Irvine (United States)
Huai-En L. Huang, Univ. of California/Irvine (United States)
Jun Zhang, Univ. of California/Irvine (United States)
Woong Gyu Jung, Univ. of California/Irvine (United States)
Zhongping Chen, Univ. of California/Irvine (United States)
John Stuart Nelson, Univ. of California/Irvine (United States)


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