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Journal of Biomedical Optics

In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography
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Paper Abstract

Glaucoma causes damage of the nerve fiber layer, which may cause loss of retinal birefringence. Therefore, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, coregistered with retinal video images of the location of PS-OCT scans. Preliminary measurements of a healthy volunteer show that the double-pass phase retardation per unit of depth of the RNFL is not constant and varies with location, with values between 0.18 and 0.37 deg/µm. A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions.

Paper Details

Date Published: 1 January 2004
PDF: 5 pages
J. Biomed. Opt. 9(1) doi: 10.1117/1.1627774
Published in: Journal of Biomedical Optics Volume 9, Issue 1
Show Author Affiliations
Barry Cense, Harvard Medical School (United States)
Teresa C. Chen, Harvard Medical School (United States)
Boris Hyle Park, Harvard Medical School (United States)
Mark C. Pierce, Harvard Medical School (United States)
Johannes F. de Boer, Harvard Medical School (United States)

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