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Journal of Biomedical Optics

Optical imaging of metastatic tumors using a folate-targeted fluorescent probe
Author(s): Michael D. Kennedy; Karim N. Jallad; David H. Thompson; Dor Ben-Amotz; Philip S. Low
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Paper Abstract

We describe the use of a tumor targeting ligand, the vitamin folic acid, to deliver an attached fluorescent probe to both primary and metastatic tumors overexpressing the folate receptor. Upon laser excitation, derived images of normal tissues generally show little or no fluorescence, whereas images of folate receptor-expressing tumors display bright fluorescence that can be easily distinguished from adjacent normal tissue. Furthermore, metastatic tumor loci of submillimeter size can also be visualized without the aid of image processing or enhancement. The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers.

Paper Details

Date Published: 1 October 2003
PDF: 6 pages
J. Biomed. Opt. 8(4) doi: 10.1117/1.1609453
Published in: Journal of Biomedical Optics Volume 8, Issue 4
Show Author Affiliations
Michael D. Kennedy, Purdue Univ. (United States)
Karim N. Jallad, Purdue Univ. (United States)
David H. Thompson, Purdue Univ. (United States)
Dor Ben-Amotz, Purdue Univ. (United States)
Philip S. Low, Purdue Univ. (United States)

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