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Journal of Biomedical Optics

Spatiotemporal characteristics of cerebral blood volume changes in rat somatosensory cortex evoked by sciatic nerve stimulation and obtained by optical imaging
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Paper Abstract

The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of α-chloralose-urethane anesthetized rats (n = 10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by electrical stimulation of the contralateral sciatic nerve with 5-Hz, 0.3-V pulses (0.5 ms) for 2 s. The stimulation evoked a monophasic decrease in optical reflectance at the cortical parenchyma and arterial sites soon after the onset of stimulation, whereas no similar response was observed at vein compartments. The optical signal changes reached 10% of the peak response 0.70±0.32 s after the start of stimulation, and no significant time lag in this 10% start latency time was observed between the response at the cortical parenchyma and artery compartments. The decrease in optical reflectance reached a peak (0.25±0.047%) 2.66±0.61 s after stimulus onset at parenchymal sites, which is 0.40±0.20 s earlier (P<0.05) than that at arterial sites (0.50±0.068% 3.06±0.70 s). Varying the locations within the cortical parenchyma and arterial compartments did not significantly affect the temporal characteristics of the evoked signal. These results suggest that stimulation of the sciatic nerve evokes an increase in local blood volume in both capillaries (cortical parenchyma) and arterioles soon after the onset of a stimulus, but the blood volume increase evoked in capillaries could not be entirely accounted for by the dilation of arterioles.

Paper Details

Date Published: 1 October 2003
PDF: 7 pages
J. Biomed. Opt. 8(4) doi: 10.1117/1.1609199
Published in: Journal of Biomedical Optics Volume 8, Issue 4
Show Author Affiliations
Pengcheng Li, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Weihua Luo, Huazhong Univ. of Science and Technology (China)
Shangbin Chen, Huazhong Univ. of Science and Technology (China)
Haiying Cheng, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)


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