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Journal of Biomedical Optics

Small-volume frequency-domain oximetry: phantom experiments and first in vivo results
Author(s): Stefan Willmann; Albert Terenji; Jens Osterholtz; Joerg Meister; Peter Hering; Hans-Joachim Schwarzmaier
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Paper Abstract

We describe a new method to determine the oxygen saturation and the total hemoglobin content of tissue in vivo absolutely at small source-detector separations (<10 mm). Phase and mean intensity of modulated laser light of various wavelengths was measured at several predetermined source-detector separations in the frequency domain. From these measured quantities, the absorption coefficient was derived using the modified time-integrated microscopic Beer-Lambert law (MBL). In addition, the interaction volume of the photons was determined using a multi-layer Monte-Carlo model of human skin. To evaluate the method, we employed homogenous solid phantoms (consisting of TiO2 particles embedded in resin) with mean scattering and absorbing properties comparable to those of human skin. Furthermore, in vivo measurements were performed in a healthy volunteer to demonstrate that the technique is applicable for the determination of the oxygen saturation and the total hemoglobin content in the skin in vivo. The proposed technique is especially suited for the on-line determination of the oxygen saturation and total hemoglobin content in applications where small applicators are required (e.g., fetal oxygen monitoring sub partu).

Paper Details

Date Published: 1 October 2003
PDF: 11 pages
J. Biomed. Opt. 8(4) doi: 10.1117/1.1608892
Published in: Journal of Biomedical Optics Volume 8, Issue 4
Show Author Affiliations
Stefan Willmann, Heinrich Heine Univ. (Germany)
Albert Terenji, Ceram Optec GmbH (Germany)
Jens Osterholtz, Heinrich-Heine Univ. Düsseldorf (Germany)
Joerg Meister, Heinrich-Heine-Univ. Dusseldorf (Germany)
Peter Hering, Heinrich-Heine-Univ. Düsseldorf (Germany)
Hans-Joachim Schwarzmaier, Klinikum Krefeld (Germany)

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