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Journal of Biomedical Optics

In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties
Author(s): Philippe Thueler; Igor Charvet; Frédéric P. Bevilacqua; Michel Saint Ghislain; G. Ory; Pierre Marquet; Paolo Meda; Ben Vermeulen; Christian D. Depeursinge
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Paper Abstract

A fast spectroscopic system for superficial and local determination of the absorption and scattering properties of tissue (480 to 950 nm) is described. The probe can be used in the working channel of an endoscope. The scattering properties include the reduced scattering coefficient and a parameter of the phase function called γ, which depends on its first two moments. The inverse problem algorithm is based on the fit of absolute reflectance measurements to cubic B-spline functions derived from the interpolation of a set of Monte Carlo simulations. The algorithm's robustness was tested with simulations altered with various amounts of noise. The method was also assessed on tissue phantoms of known optical properties. Finally, clinical measurements performed endoscopically in vivo in the stomach of human subjects are presented. The absorption and scattering properties were found to be significantly different in the antrum and in the fundus and are correlated with histopathologic observations. The method and the instrument show promise for noninvasive tissue diagnostics of various epithelia.

Paper Details

Date Published: 1 July 2003
PDF: 9 pages
J. Biomed. Opt. 8(3) doi: 10.1117/1.1578494
Published in: Journal of Biomedical Optics Volume 8, Issue 3
Show Author Affiliations
Philippe Thueler, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Igor Charvet, Univ. de Genève (Switzerland)
Frédéric P. Bevilacqua, Univ. of California/Irvine (United States)
Michel Saint Ghislain, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
G. Ory, Hôpitaux Univ. de Genève (Switzerland)
Pierre Marquet, Univ. de Lausanne (Switzerland)
Paolo Meda, Univ. de Genève (Switzerland)
Ben Vermeulen, Hôpitaux Univ. de Genève (Switzerland)
Christian D. Depeursinge, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


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