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Journal of Biomedical Optics

Temperature modulation of the visible and near infrared absorption and scattering coefficients of human skin
Author(s): Omar S. Khalil; Shu-Jen Yeh; Michael G. Lowery; Xiaomao Wu; Charles F. Hanna; Stanislaw Kantor; Tzyy-Wen Jeng; Johannes Sake Kanger; Rene Alexander Bolt; Frits F. M. de Mul
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Paper Abstract

We determine temperature effect on the absorption and reduced scattering coefficients (μa and μ's) of human forearm skin. Optical and thermal simulation data suggest that μa and μ's are determined within a temperature-controlled depth of ≈ 2 mm. Cutaneous μ's change linearly with temperature. Change in μa was complex and irreversible above body normal temperatures. Light penetration depth δ in skin increased on cooling, with considerable person-to-person variations. We attribute the effect of temperature on μ's to change in refractive index mismatch, and its effect on μa to perfusion changes. The reversible temperature effect on μ's was maintained during more than 90 min. contact between skin and the measuring probe, where temperature was modulated between 38 and 22°C for multiple cycles While temperature modulated μ's instantaneously and reversibly, μa exhibited slower response time and consistent drift. There was a statistically significant upward drift in μa and a mostly downward drift in μ's over the contact period. The drift in temperature-induced fractional change in μ's was less statistically significant than the drift in μ's. Δμ's values determined under temperature modulation conditions may have less nonspecific drift than μ's which may have significance for noninvasive determination of analytes in human tissue.

Paper Details

Date Published: 1 April 2003
PDF: 15 pages
J. Biomed. Opt. 8(2) doi: 10.1117/1.1559997
Published in: Journal of Biomedical Optics Volume 8, Issue 2
Show Author Affiliations
Omar S. Khalil, Abbott Labs. (United States)
Shu-Jen Yeh, Abbott Labs. (United States)
Michael G. Lowery, Abbott Labs. (United States)
Xiaomao Wu, Abbott Labs. (United States)
Charles F. Hanna, Abbott Labs. (United States)
Stanislaw Kantor, Abbott Labs. (United States)
Tzyy-Wen Jeng, Abbott Labs. (United States)
Johannes Sake Kanger, Univ. Twente (Netherlands)
Rene Alexander Bolt, Univ. Twente (Netherlands)
Frits F. M. de Mul, Univ. Twente (Netherlands)

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