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Journal of Biomedical Optics

Optoacoustic tomography using time-resolved interferometric detection of surface displacement
Author(s): Barry P. Payne; Vasan Venugopalan; Bora B. Mikic; Norman S. Nishioka
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Paper Abstract

We introduce a minimally invasive technique for optoacoustic imaging of turbid media using optical interferometric detection of surface displacement produced by thermoelastic stress transients. The technique exploits endogenous or exogenous optical contrast of heterogeneous tissues and the low attenuation of stress wave propagation to localize and image subsurface absorbers in optically turbid media. We present a system that utilizes a time-resolved high-resolution interferometer capable of angstrom-level displacement resolution and nanosecond temporal resolution to detect subsurface blood vessels within model tissue phantoms and a human forearm in vivo.

Paper Details

Date Published: 1 April 2003
PDF: 8 pages
J. Biomed. Opt. 8(2) doi: 10.1117/1.1559727
Published in: Journal of Biomedical Optics Volume 8, Issue 2
Show Author Affiliations
Barry P. Payne, Massachusetts Institute of Technology (United States)
Vasan Venugopalan, Univ. of California/Irvine (United States)
Bora B. Mikic, Massachusetts Institute of Technology (United States)
Norman S. Nishioka, Massachusetts General Hospital (United States)

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