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Journal of Biomedical Optics

Assessment of in situ temporal calibration method for time-resolved optical tomography
Author(s): Jeremy C. Hebden; Felipe Gonzalez; Adam Gibson; Elizabeth M. C. Hillman; Rozarina Md Yusof; Nick Everdell; David T. Delpy; Giovanni Zaccanti; Fabrizio Martelli
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Paper Abstract

A 32-channel time-resolved optical imaging device is developed at University College London to produce functional images of the neonatal brain and the female breast. Reconstruction of images using time-resolved measurements of transmitted light requires careful calibration of the temporal characteristics of the measurement system. Since they can often vary over a period of time, it is desirable to evaluate these characteristics immediately after, or prior to, the acquisition of image data. A calibration technique is investigated that is based on the measurement of light back-reflected from the surface of the object being imaged. This is facilitated by coupling each detector channel with an individual source fiber. A Monte Carlo model is employed to investigate the influence of the optical properties of the object on the back-reflected signal. The results of simulations indicate that their influence may be small enough to be ignored in some cases, or could be largely accounted for by a small adjustment to the calibrated data. The effectiveness of the method is briefly demonstrated by imaging a solid object with tissue-equivalent optical properties.

Paper Details

Date Published: 1 January 2003
PDF: 6 pages
J. Biomed. Opt. 8(1) doi: 10.1117/1.1528206
Published in: Journal of Biomedical Optics Volume 8, Issue 1
Show Author Affiliations
Jeremy C. Hebden, Univ. College London (United Kingdom)
Felipe Gonzalez, Telnor (Mexico)
Adam Gibson, Univ. College London (United Kingdom)
Elizabeth M. C. Hillman, Argose, Inc. (United States)
Rozarina Md Yusof, Univ. College London (United Kingdom)
Nick Everdell, Univ. College London (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)
Fabrizio Martelli, Univ. Degli Studi di Firenze (Italy)


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