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Journal of Biomedical Optics

Blood pO2 and blood flow at the optic disc
Author(s): Stephane R. Chamot; Stephen D. Cranstoun; Benno L. Petrig; Constantin J. Pournaras; Charles E. Riva
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Paper Abstract

A fundus camera-based phosphorometer to noninvasively and quasicontinuously measure the blood partial pressure of oxygen (pOA fundus camera-based phosphorometer to noninvasively and quasicontinuously measure the blood partial pressure of oxygen (pO2,blood) in the microvasculature of the pig optic nerve using the principle of the phosphorescence quenching by O2 is described. A porphyrin dye is injected into the venous circulation and the decay of its phosphorescence emission is detected locally in the eye, after excitation with a flash of light. Combined with blood flow measurements by means of a laser Doppler flowmeter mounted on the phosphorometer, we demonstrate the capability of the instrument to determine the time course of optic nerve blood flow and pO2,blood in response to various physiological stimuli, such as hyperoxia and hypercapnia. This instrument appears to be a useful tool for the investigation of the oxygenation of the optic nerve.

Paper Details

Date Published: 1 January 2003
PDF: 7 pages
J. Biomed. Opt. 8(1) doi: 10.1117/1.1527935
Published in: Journal of Biomedical Optics Volume 8, Issue 1
Show Author Affiliations
Stephane R. Chamot, Institute de Recherche en Ophtalmologie (Switzerland)
Stephen D. Cranstoun, Univ. of Pennsylvania (United States)
Benno L. Petrig, Institut de Recherche en Opthalmologie (Switzerland)
Constantin J. Pournaras, Geneva Univ. (Switzerland)
Charles E. Riva, Institut de Recherche en Ophthalmologie (Switzerland)


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