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Journal of Biomedical Optics

Light-scattering instrument to detect thromboemboli in blood
Author(s): Kenneth Solen; Sivaprasad Sukavaneshvar; Yu Zheng; Brian Hanrahan; Matthew Hall; Paul Goodman; Benjamin Goodman; Fazal Mohammad
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Paper Abstract

The characteristics and capabilities of a light-scattering microemboli detector (LSMD) are delineated by detailing its state-of-the-art configuration, by discussing the theoretical and empirical aspects of instrument calibration, and by summarizing various experimental studies that have benefited from this instrument. In the past, thromboembolism, which often results when blood contacts medical devices, has eluded scientific scrutiny due to the absence of instruments that could detect and quantify thromboemboli in circulating blood. More recently, the ability of the LSMD to provide continuous, noninvasive detection of thromboemboli in whole blood (meaning that the LSMD probe does not contact the blood) was exploited in various in vitro and ex vivo models to explore thromboembolic phenomena. Through this work, the LSMD evolved as a sensitive and an economical research tool for the study of thromboembolic phenomena.

Paper Details

Date Published: 1 January 2003
PDF: 10 pages
J. Biomed. Opt. 8(1) doi: 10.1117/1.1527934
Published in: Journal of Biomedical Optics Volume 8, Issue 1
Show Author Affiliations
Kenneth Solen, Brigham Young Univ. (United States)
Sivaprasad Sukavaneshvar, Utah Artificial Heart Institute (United States)
Yu Zheng, Utah Artificial Heart Institute (United States)
Brian Hanrahan, Brigham Young Univ. (United States)
Matthew Hall, Brigham Young Univ. (United States)
Paul Goodman, Brigham Young Univ. (United States)
Benjamin Goodman, Brigham Young Univ. (United States)
Fazal Mohammad, Utah Artificial Heart Institute (United States)


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