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Journal of Biomedical Optics

Hyperspectral techniques in analysis of oral dosage forms
Author(s): Sara J. Hamilton; Amanda E. Lowell; Robert A. Lodder
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Paper Abstract

Pharmaceutical oral dosage forms are used in this paper to test the sensitivity and spatial resolution of hyperspectral imaging instruments. The first experiment tested the hypothesis that a near-infrared (IR) tunable diode-based remote sensing system is capable of monitoring degradation of hard gelatin capsules at a relatively long distance (0.5 km). Spectra from the capsules were used to differentiate among capsules exposed to an atmosphere containing 150 ppb formaldehyde for 0, 2, 4, and 8 h. Robust median-based principal component regression with Bayesian inference was employed for outlier detection. The second experiment tested the hypothesis that near-IR imaging spectrometry of tablets permits the identification and composition of multiple individual tablets to be determined simultaneously. A near-IR camera was used to collect thousands of spectra simultaneously from a field of blister-packaged tablets. The number of tablets that a typical near-IR camera can currently analyze simultaneously was estimated to be approximately 1300. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. The single-capsule analysis provides an indication of how far apart the sample and instrumentation can be and still maintain adequate signal-to-noise ratio (S/N), while the multiple-tablet imaging experiment gives an indication of how many samples can be analyzed simultaneously while maintaining an adequate S/N and pixel coverage on each sample.

Paper Details

Date Published: 1 October 2002
PDF: 10 pages
J. Biomed. Opt. 7(4) doi: 10.1117/1.1501884
Published in: Journal of Biomedical Optics Volume 7, Issue 4
Show Author Affiliations
Sara J. Hamilton, Univ. of Kentucky (United States)
Amanda E. Lowell, Univ. of Kentucky (United States)
Robert A. Lodder, Univ. of Kentucky (United States)


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