Share Email Print

Journal of Biomedical Optics

Development and calibration of an automated Mueller matrix polarization imaging system
Author(s): Justin S. Baba; Jung-Rae Chung; Aimee H. DeLaughter; Brent D. Cameron; Gerard L. Cote
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The high fatality rate associated with the late detection of skin cancer makes early detection crucial in preventing death. The current method for determining if a skin lesion is suspect to cancer is initially based on the patient’s and physician’s subjective observation of the skin lesion. Physicians use a set of parameters called the ABCD (asymmetry, border, color, diameter) rule to help facilitate diagnosis of potential cancerous lesions. Lesions that are suspicious then require a biopsy, which is a painful, invasive, and a time-consuming procedure. In an attempt to reduce the aforementioned undesirable elements currently associated with skin cancer diagnosis, a novel optical polarization-imaging system is described that has the potential to noninvasively detect cancerous lesions. The described system generates the full 16-element Mueller matrix in less than 70 s. The operation of the system was tested in transmission, specular reflection, and diffuse reflectance modes, using known samples, such as a horizontal linear polarizer, a mirror, and a diffuser plate. In addition, it was also used to image a benign lesion on a human subject. The results of the known samples are in good agreement with their theoretical values with an average accuracy of 97.96% and a standard deviation of 0.0084, using 16 polarization images. The system accuracy was further increased to 99.44% with a standard deviation of 0.005, when 36 images were used to generate the Mueller matrix.

Paper Details

Date Published: 1 July 2002
PDF: 9 pages
J. Biomed. Opt. 7(3) doi: 10.1117/1.1486248
Published in: Journal of Biomedical Optics Volume 7, Issue 3
Show Author Affiliations
Justin S. Baba, Texas A&M Univ. (United States)
Jung-Rae Chung, Texas A&M Univ. (United States)
Aimee H. DeLaughter, Texas A&M Univ. (United States)
Brent D. Cameron, Texas A&M Univ. (United States)
Gerard L. Cote, Texas A&M Univ. (United States)

© SPIE. Terms of Use
Back to Top