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Journal of Biomedical Optics

Real-time in vivo color Doppler optical coherence tomography
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Paper Abstract

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissuesimulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.

Paper Details

Date Published: 1 January 2002
PDF: 7 pages
J. Biomed. Opt. 7(1) doi: 10.1117/1.1428291
Published in: Journal of Biomedical Optics Volume 7, Issue 1
Show Author Affiliations
Andrew M. Rollins, Case Western Reserve Univ. (United States)
Siavash Yazdanfar, Case Western Reserve Univ. (United States)
Jennifer Kehlet Barton, Univ. of Arizona (United States)
Joseph A. Izatt, Case Western Reserve Univ. (United States)


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