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Journal of Biomedical Optics

Quantification of optical properties of a breast tumor using random walk theory
Author(s): Victor V. Chernomordik; David W. Hattery; Dirk Grosenick; Heidrun Wabnitz; Herbert H. Rinneberg; K. Thomas Moesta; Peter M. Schlag; Amir H. Gandjbakhche
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Paper Abstract

For the first time we use a random walk methodology based on time-dependent contrast functions to quantify the optical properties of breast tumors (invasive ductal carcinoma) of two patients. Previously this theoretical approach was successfully applied for analysis of embedded objects in several phantoms. Data analysis was performed on distributions of times of flight for photons transmitted through the breast which were recorded in vivo using a time-domain scanning mammograph at 670 and 785 nm. The size of the tumors, their optical properties, and those of the surrounding tissue were reconstructed at both wavelengths. The tumors showed increased absorption and scattering. From the absorption coefficients at both wavelengths blood oxygen saturation was estimated for the tumors and the surrounding tissue.

Paper Details

Date Published: 1 January 2002
PDF: 8 pages
J. Biomed. Opt. 7(1) doi: 10.1117/1.1427049
Published in: Journal of Biomedical Optics Volume 7, Issue 1
Show Author Affiliations
Victor V. Chernomordik, National Institutes of Health (Israel)
David W. Hattery, National Institutes of Health (United States)
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Herbert H. Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)
K. Thomas Moesta, Humboldt Univ. (Germany)
Peter M. Schlag, Humboldt Univ. (Germany)
Amir H. Gandjbakhche, National Institutes of Health (Israel)

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