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Journal of Biomedical Optics

Non-invasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopy
Author(s): Tuan H. Pham; Renee Hornung; Hongphuc P. Ha; Tanya Burney; Dan Serna; Ledford Powell; Matthew Brenner; Bruce J. Tromberg
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Paper Abstract

Hemorrhagic hypovolemia and inotropic agent administration were used to manipulate cardiac output (CO) and oxygen delivery in rabbits to investigate the correlation between noninvasive frequency domain photon migration (FDPM) spectroscopy and invasive hemodynamic monitoring parameters. Frequency-domain photon migration provides quantitative measurements of light absorption and reduced scattering (µa and µ's, respectively) in tissue. Wavelength dependent µa values were used to calculate in vivo tissue concentration of deoxyhemoglobin [Hb], oxyhemoglobin [HbO2], total hemoglobin [TotHb], and water [H2O] as well as mixed arterial-venous oxygen saturation (StO2) in tissue. FDPM-derived physiologic properties were correlated with invasive measurements of CO and mean pulmonary artery pressure (mPAP), FDPM-derived [TotHb] and StO2 correlated significantly with hemorrhaged volume (HV), mPAP, and CO. Correlation coefficients for [TotHb] vs HV, mPAP, and CO were ?0.77, 0.86, and 0.70, respectively. Correlation coefficients of StO2 vs HV, mPAP, and CO were ?0.71, 0.55, and 0.61, respectively. Dobutamine induced changes resulted in correlation coefficients between FDPM-derived and invasively measured physiologic parameters that are comparable to those induced by hypovolemia. FDPM spectroscopy is sensitive to changes in mPAP and CO of as little as 15%. These results suggest that FDPM spectroscopy may be used in clinical settings to noninvasively monitor central hemodynamic parameters and to directly assess oxygenation of tissues.

Paper Details

Date Published: 1 January 2002
PDF: 11 pages
J. Biomed. Opt. 7(1) doi: 10.1117/1.1427046
Published in: Journal of Biomedical Optics Volume 7, Issue 1
Show Author Affiliations
Tuan H. Pham, Univ. of California/Irvine (United States)
Renee Hornung, Univ. of California/Irvine and Univ. Hospital Zurich (United States)
Hongphuc P. Ha, Univ. of California/Irvine (United States)
Tanya Burney, Univ. of California/Irvine (United States)
Dan Serna, Univ. of California/Irvine (United States)
Ledford Powell, Univ. of California/Irvine (United States)
Matthew Brenner, Univ. of California/Irvine (United States)
Bruce J. Tromberg, Univ. of California/Irvine (United States)


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