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Optical Engineering

Near-infared spectroscopy studies on cerebral blood oxygenation changesduring brain activation: possible limitations of blood oxygenation level dependent functional magnetic resonanc
Author(s): Yuxiao Xie; Kaoru Sakatania; Wemara Lichty; Huancong Zuo; Zuoping Xie; Jing Bai
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Paper Abstract

The noninvasive method of functional near-infrared spectroscopy (fNIRS) has recently been used to measure changes of optical parameters such as light absorption of brain tissue. Hemodynamics and oxygenation changes related to brain activation can be evaluated using fNIRS, with the most widely evaluated parameters being oxygenated hemoglobin (Oxy-Hb), deoxygenated hemoglobin (Deoxy-Hb), as well as total hemoglobin, which is the sum of Oxy-Hb and Deoxy-Hb and which reflects cerebral blood flow. The typical response is an increase in concentrations of Oxy-Hb and Total-Hb accompanied by a decrease in Deoxy-Hb; however, a variety of oxygenation and deoxygenation changes have been found, particularly regarding clinical studies and developmental studies of infants and older adults. The findings of increases of Deoxy-Hb as well as decreases of Oxy-Hb and Total-Hb are important for understanding clinical and development changes. In addition, the findings suggest possible limitations or problems with blood oxygenation level dependent (BOLD)-fMRI for clinical and developmental studies, and for revealing the complexity of hemodynamics and oxygenation responses.

Paper Details

Date Published: 1 October 2001
PDF: 6 pages
Opt. Eng. 40(10) doi: 10.1117/1.1403007
Published in: Optical Engineering Volume 40, Issue 10
Show Author Affiliations
Yuxiao Xie, Sino-Japanese Friendship Hospital (China)
Kaoru Sakatania, Tsinghua Univ. (China)
Wemara Lichty, Bustin Co. (United States)
Huancong Zuo, China-Japan Friendship Hospital (China)
Zuoping Xie, Tsinghua Univ. (China)
Jing Bai, Tsinghua Univ. (China)


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