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Journal of Biomedical Optics

Study of the mechanism of a chemotherapeutic drug in living cancer cells by two-photon laser scanning microspectrofluorometry
Author(s): Xiaopeng Wang; Haridas E. Pudavar; Rakesh Kapoor; Linda J. Krebs; Earl J. Bergey; Charles Liebow; Paras N. Prasad; Attila Nagy; Andrew V. Schally
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Paper Abstract

In this study, we present a spectroscopic study of the entry pattern of a chemotherapeutic drug (AN-152) and its carrier hormone ([D-Lys6]LH-RH) into living cancer cells, with the help of our twophoton probes and a home-built localized microspectrofluorometer coupled with two photon laser scanning microscope (TPLSM). Due to the inherent localization ability of TPLSM, we were able to identify the drug and carrier location in different compartments of the cancer cells in vitro. The apparent doxorubicin-assisted nucleic accumulation of AN-152 suggests a possible nuclear action of the drug on cell proliferation.

Paper Details

Date Published: 1 July 2001
PDF: 7 pages
J. Biomed. Opt. 6(3) doi: 10.1117/1.1385511
Published in: Journal of Biomedical Optics Volume 6, Issue 3
Show Author Affiliations
Xiaopeng Wang, SUNY/Buffalo (United States)
Haridas E. Pudavar, SUNY/Buffalo (United States)
Rakesh Kapoor, SUNY/Buffalo (United States)
Linda J. Krebs, SUNY/Buffalo (United States)
Earl J. Bergey, SUNY/Buffalo (United States)
Charles Liebow, SUNY/Buffalo (United States)
Paras N. Prasad, SUNY/Buffalo (United States)
Attila Nagy, Research Institute for Solid State Physics and Optics (Hungary)
Andrew V. Schally, Tulane Univ. (United States)

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