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Journal of Biomedical Optics

Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments
Author(s): Bernd Ebert; Uwe Sukowski; Dirk Grosenick; Heidrun Wabnitz; K. Thomas Moesta; Kai Licha; Andreas Becker; Wolfhard Semmler; Peter M. Schlag; Herbert H. Rinneberg
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Paper Abstract

Optical mammography with near-infrared (NIR) light using time-domain, frequency-domain, or continuous-wave techniques is a novel imaging modality to locate human breast tumors. By investigating excised specimens of normal and diseased mamma tissue we were able to demonstrate that differences in their scattering properties are a poor predictive parameter for normal and diseased mamma tissue. This paper describes the application of a NIR dye to improve the differentiation between breast tumors and normal tissue in a rat model. The NIR dye furnished a high tumor-to-tissue contrast ratio (6:1) in fluorescence images. Furthermore, this dye was used to develop liquid scattering phantoms with absorbing and fluorescent inhomogeneities. Using frequency-domain and time-domain instrumentation these inhomogeneities were localized at sufficient contrast by their increased absorption and fluorescence. Contrast between inhomogeneities and surrounding medium could be improved by combining fluorescence and transmittance images.

Paper Details

Date Published: 1 April 2001
PDF: 7 pages
J. Biomed. Opt. 6(2) doi: 10.1117/1.1350561
Published in: Journal of Biomedical Optics Volume 6, Issue 2
Show Author Affiliations
Bernd Ebert, Physikalisch-Technische Bundesanstalt (Germany)
Uwe Sukowski, Physikalisch-Technische Bundesanstalt (Germany)
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
K. Thomas Moesta, Humboldt Univ. (Germany)
Kai Licha, Schering AG (Germany)
Andreas Becker, Freie Univ. Berlin (Germany)
Wolfhard Semmler, Freie Univ. Berlin (Germany)
Peter M. Schlag, Humboldt-Univ. zu Berlin (Germany)
Herbert H. Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)

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