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Journal of Biomedical Optics

Pulsed photothermal radiometry as a method for investigating blood vessel-like structures
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Paper Abstract

Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser–tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.

Paper Details

Date Published: 1 April 2001
PDF: 10 pages
J. Biomed. Opt. 6(2) doi: 10.1117/1.1344193
Published in: Journal of Biomedical Optics Volume 6, Issue 2
Show Author Affiliations
Christoph H. Schmitz, SUNY/Downstate Medical Ctr. (United States)
Uwe Oberheide, Laser Zentrum Hannover e.V. (Germany)
Stefan Lohmann, European Patent Office (Germany)
Holger Lubatschowski, Laser Zentrum Hannover e.V. (Germany)
Wolfgang Ertmer, Univ. Hannover (Germany)

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