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Journal of Biomedical Optics

Optical coherence tomography of the rat cochlea
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Paper Abstract

Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague–Dawley rat was harvested. Axial OCT cross sectional images (over regions of interest, 1x1 mm– 2x8 mm) were obtained with a spatial resolution of 10–15 µm. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner’s and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth.

Paper Details

Date Published: 1 October 2000
PDF: 4 pages
J. Biomed. Opt. 5(4) doi: 10.1117/1.1310165
Published in: Journal of Biomedical Optics Volume 5, Issue 4
Show Author Affiliations
Brian Jet-Fei Wong, Univ. of California/Irvine (United States)
Johannes F. de Boer, Beckman Laser Institute and Medical Clinic (United States)
Boris Hyle Park, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute (United States)
J. Stuart Nelson, Univ. of California/Irvine (United States)

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