The Moscone Center
San Francisco, California, United States
27 January - 1 February 2018
Plenary Events
BiOS Hot Topics
Date: Saturday 27 January 2018
Time: 7:00 PM - 9:05 PM
Location: Room 3022 (West Level 3)
7:00 to 7:05 pm
Welcome and Opening Remarks

BiOS 2018 Symposium Chair
James Fujimoto, Massachusetts Institute of Technology (United States)

BiOS 2018 Symposium Chair
R. Rox Anderson, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard School of Medicine (United States)

7:05 to 7:10 pm
Presentation of 2018 Biophotonics Technology Innovator Award
Presented by SPIE President to Elizabeth M. C. Hillman, Columbia University (United States)

The Biophotonics Technology Innovator Award is presented annually for extraordinary achievements in biophotonics technology development that show strong promise or potential impact in Biology, Medicine, and Biomedical Optics. The award targets achievements that span disciplines and may include elements of basic research, technology development, and clinical translation.

7:10 to 7:15 pm
Presentation of the SPIE-Franz Hillenkamp Postdoctoral Fellowship
in Problem-Driven Biophotonics and Biomedical Optics

7:15 to 7:20 pm
Presentation of 2018 Britton Chance Biomedical Optics Award
Presented by SPIE President to Tayyaba Hasan, Wellman Ctr. for Photomedicine (United States)

The Britton Chance Biomedical Optics Award is presented annually in recognition of outstanding lifetime contributions to the field of biomedical optics through the development of innovative, high impact technologies. The award particularly honors pioneering contributions to optical methods and devices that have facilitated advancements in biology or medicine. The SPIE Awards Committee has made this recommendation in recognition of Dr. Hasan's impressive achievements in the field of photodynamic therapy.

7:20 to 7:40 pm

Photodynamic therapy: the next 10 Years in 10 Minutes
Tayyaba Hasan, Wellman Ctr. for Photomedicine (United States)

7:40 to 7:45 pm

Hot Topics Facilitator Remarks
Sergio Fantini, Tufts Univ. (United States)

7:45 to 7:55 pm

Taking the photonics out of photodynamic therapy
Brian Wilson, Univ. of Toronto. (Canada)

7:55 to 8:05 pm

Biophotonics applications of gas in scattering media absorption spectroscopy (GASMAS)
Katarina and Sune Svanberg, Lund Univ. (Sweden) and South China Normal Univ. (China

8:05 to 8:15 pm

Large-scale single-cell analysis with extreme imaging
Keisuke Goda, Univ. of California/Los Angeles. (United States) and Univ. of Tokyo (Japan)

8:15 to 8:25 pm

Optical coherence tomography in the oral cavity
Julia Walther, Technical Univ. Dresden (Germany)

8:25 to 8:35 pm

Optical, label-free, morpho-functional metabolic imaging
Irene Georgakoudi, Tufts Univ. (United States)

8:35 to 8:45 pm

3D multiphoton optogenetic control of neural ensemble activity
Hillel Adesnik, Univ. of California/Berkeley (United States)

8:45 to 8:55 pm

Brainsmatics-visualizing brain-wide networks
Qingming Luo, Britton Chance Ctr. For Biomedical Photonics, Huazhong Univ. of Science and Technology (China)

8:55 to 9:05 pm

Latest on noninvasive, optical blood flow measurements breaking cost, portability, and scalability limits
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Neurotechnologies Plenary Session
Date: Sunday 28 January 2018
Time: 3:30 PM - 5:30 PM
Location: Room 3022 (West Level 3)
Initiated in 2017, this session will highlight the breadth of exciting advances occurring in the field of neurophotonics and provide a unique forum for communication and networking for leaders and innovators in the neurophotonics community.

SPIE Brain Symposium Chairs

David Boas, Boston Univ. (USA)

Rafael Yuste, Columbia Univ. (USA)

Welcome and Opening Remarks, David Boas, Boston Univ. (USA)


3:35 to 3:45 pm
Neurophotonic strategies for observing and controlling neural circuits
Ed Boyden, Massachusetts Institute of Technology (USA)

3:45 to 3:55 pm
Fast in vivo volumetric imaging of the brain
Na Ji, Univ. of California, Berkeley (USA)

3:55 to 4:05 pm
High-speed optical imaging of brain-wide activity
Elizabeth Hillman, Columbia Univ. (USA)

4:05 to 4:15 pm
Super-duper bioluminescent probes for next generation neuroscience
Takeharu Nagai, Osaka Univ. (Japan)

4:15 to 4:25 pm
Photoacoustic microscopy of the cerebral microvasculature
Song Hu, Univ. of Virginia (USA)

4:25 to 4:35 pm
Photobiomodulation and the brain: a new clinical paradigm
Michael Hamblin, Wellman Ctr. for Photomedicine (USA)

4:35 to 4:45 pm
Old tools for new uses: fNIRS to investigate transcranial brain stimulations
Hanli Liu, Univ. of Texas at Arlington (USA)

4:45 to 4:55 pm
Optical assessment of cerebral autoregulation
Sergio Fantini, Tufts Univ. (USA)

4:55 to 5:05 pm
Optics and photonics for BRAIN science: BRAIN initiative funding priorities
Edmund Talley, National Institutes of Health (USA)

5:05 to 5:30
Discussion and Q&A

Abstracts and Speaker Biographies
BiOS Sunday Plenary Session
Date: Sunday 28 January 2018
Time: 7:00 PM - 8:15 PM
Location: Room 3022 (West Level 3)
7:00 to 7:05
Recognition of Lihong Wang, California Institute of Technology
Retiring Editor of the Journal of Biomedical Optics

7:05 to 7:10
Welcome and introduction of Stefan Hell
Ammasi Periasamy, Univ. of Virginia

7:10 to 7:40
Super-resolution post Nobel

Stefan W. Hell, Max Planck Institute Gottingen (Germany)
2014 Nobel Laureate in Chemistry

The 2014 Nobel Prize in Chemistry was awarded jointly to W.E. Moerner, Eric Betzig and myself “for the development of super-resolved fluorescence microscopy”. More than 125 years after Ernst Abbe’s definition of the supposedly insurmountable diffraction resolution limit, “[our] microscopes crossed the threshold”, as the Nobel poster put it. The result has been the breathtaking development of far-field optical super-resolution microscopy or, in short, ‘nanoscopy‘ as an entire field over the past years.

A fresh look at the foundations [1] shows that an in-depth description of the basic principles of nanoscopy spawns new powerful concepts such as MINFIELD [2], MINFLUX [3] and DyMIN [4]. Although they differ in some aspects, these concepts harness a local intensity minimum (of a doughnut or a standing wave) for determining the coordinate of the fluorophore(s) to be registered. Most strikingly, by using an intensity minimum of the excitation light to establish the fluorophore position, MINFLUX nanoscopy has obtained the ultimate (super)resolution: the size of a molecule [3].

[1] Hell, S.W. Far-Field Optical Nanoscopy. Science 316, 1153-1158 (2007).
[2] Göttfert, F., Pleiner, T., Heine, J., Westphal, V., Görlich, D., Sahl, S.J., Hell, S.W. Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent. PNAS 114, 2125-2130 (2017).
[3] Balzarotti, F., Eilers, Y., Gwosch, K. C., Gynnå, A. H., Westphal, V., Stefani, F. D., Elf, J., Hell, S.W. Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes. Science 355, 606-612 (2017).
[4] Heine, J., Reuss, M., Harke, B., D’Este, E., Sahl, S.J., Hell, S.W. Adaptive-illumination STED nanoscopy. PNAS (advance online, 2017).

Stefan W. Hell is a director at the Max Planck Institute for Biophysical Chemistry in Göttingen and at the Max Planck Institute for Medical Research in Heidelberg. He is credited with having conceived, validated and applied the first viable concept for breaking Abbe’s diffraction-limited resolution barrier in a light-focusing microscope and has received several awards: most recently he shared the 2014 Kavli Prize in Nanoscience and the 2014 Nobel Prize in Chemistry.

7:40 to 7:45
Introduction of Karl Deisseroth
David Boas, Boston Univ.

7:45 to 8:15
Nature's gift: how the discovery of structural principles in a microbial protein helped illuminate the pathophysiology of psychiatry

Karl Deisseroth, Stanford Univ. (USA)

Karl Deisseroth is the D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University, and Investigator of the Howard Hughes Medical Institute. He received his undergraduate degree from Harvard, his PhD from Stanford, and his MD from Stanford; he also completed postdoctoral training, medical internship, and adult psychiatry residency at Stanford, and he is board-certified by the American Board of Psychiatry and Neurology. He continues as a practicing psychiatrist at Stanford with specialization in affective disorders and autism-spectrum disease, employing medications along with neural stimulation. Over a period of twelve years, his laboratory created and developed optogenetics, CLARITY, and a broad range of supportive and enabling methods. He also has employed his technologies to discover the neural cell types and connections that cause adaptive and maladaptive behaviors, and has disseminated the technologies to thousands of laboratories around the world. For his discoveries, Deisseroth has received the NIH Director's Pioneer Award (2005), the Zuelch Prize (2012), the PerlPrize (2012), the BRAIN prize (2013), the Pasarow Prize (2013), the Breakthrough Prize (2015) the BBVA Award (2016), the Massry Prize (2016) and the Harvey Prize from the Technion/Israel (2017), and among other honors, was the sole recipient for optogenetics of the 2010 Koetser Prize, the 2010 Nakasone Prize, the 2011 Alden Spencer Prize, the 2013 Richard Lounsbery Prize, the 2014 Dickson Prize in Science, the 2015 Keio Prize, the 2015 Lurie Prize, the 2015 Albany Prize, the 2015 Dickson Prize in Medicine, the 2017 Redelsheimer Prize, and the 2017 Fresenius Prize. He was selected a Howard Hughes Medical Institute Investigator in 2013, and was elected to the US National Academy of Medicine in 2010 and to the US National Academy of Sciences in 2012.
Nano/Biophotonics Plenary Session
Date: Tuesday 30 January 2018
Time: 10:30 AM - 11:30 AM
Location: Room 3001 (West Level 3)
Welcome and Introduction

Dan Nicolau, McGill Univ. (Canada)

Shaped Light for BioNanophotonics: a new chapter in imaging

Kishan Dholakia, Univ. of St. Andrews (United Kingdom)

There has never been a more exciting time for biomedical imaging using light. The last decade has seen the community break through the diffraction limit as well as perform groundbreaking imaging studies for fundamental biology and healthcare in innovative ways whilst minimizing photodamage.

I will describe some of the latest advances and future opportunities using light shaped in time and space for wide field biomedical imaging. This includes the use of propagation invariant fields such as Bessel and Airy modes for obtaining wide field of view imaging with high resolution in geometries such as light sheet imaging. In addition I will describe work on complex media where we can shape light by controlling the degrees of freedom for an incident field for imaging through highly scattering tissue, at depth and developing new forms of fibre-based imaging and sensing. These methods are poised to make shaped light a powerful approach for the future of biomedical imaging.

Kishan Dholakia is a Professor of Physics in the School of Physics and Astronomy at University of St Andrews. His interests span a range of fundamental and applied photonics with a special emphasis on beam shaping of light including optical vortices and propagation invariant light fields. His group has been very active in the fields of optical manipulation and biophotonics over the last decade. He won the European Optics Prize in 2003 and is a Fellow of the Optical Society of America, SPIE, and the Royal Society of Edinburgh. He was a Royal Society Wolfson-Merit Award Holder from 2008 to 2013. He is the 2016 recipient of the R.W. Wood Prize of OSA, the 2017 recipient of the Institute of Physics Thomas Young Medal and Prize and the 2018 recipient of the SPIE Dennis Gabor Award.
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