The Moscone Center
San Francisco, California, United States
28 January - 2 February 2017
Plenary Events
BiOS Hot Topics
Date: Saturday 28 January 2017
Time: 7:00 PM - 9:05 PM
Location: Room 3022 (West Level 3)
7:00 to 7:10 pm
Welcome and Opening Remarks


James Fujimoto, Massachusetts Institute of Technology (United States)
BiOS 2017 Symposium Chair


R. Rox Anderson, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard School of Medicine (United States)
BiOS 2017 Symposium Chair

7:10 to 7:15 pm
Presentation of 2017 Britton Chance Biomedical Optics Award
Presented by SPIE President to

Christopher H. Contag, Michigan State Univ., and Stanford Univ., Prof. Emeritus (United States)

The Britton Chance Biomedical Optics Award is presented annually in recognition of outstanding lifetime contributions to the field of biomedical optics through the development of innovative, high impact technologies. The award particularly honors pioneering contributions to optical methods and devices that have facilitated advancements in biology or medicine. The SPIE Awards Committee has made this recommendation in recognition of his extraordinary contributions to the invention of in vivo optical imaging using bioluminescent reporters, a significant advance that has been widely adopted throughout the world to advance our understanding of biology, accelerate drug discovery and development, and create new tools to improve human health.

7:15 to 7:35 pm

In-vivo Optical Imaging Using Bioluminescent Reporters,
Christopher H. Contag, Michigan State Univ., and Stanford Univ., Prof. Emeritus, (United States)

7:40 to 7:45 pm
Hot Topics Facilitator Remarks

Sergio Fantini, Tufts Univ. (United States)

7:45 to 7:55 pm

Advances in Noninvasive Optical Biopsy
Robert Alfano, CCNY/City Univ. of New York (United States)

7:55 to 8:05 pm

Cardiac Optogenetics
Emilia Entcheva, George Washington Univ. (United States)

8:05 to 8:15 pm

UV Surface Excitation for Slide-Free Tissue Microscopy
Richard Levenson, Univ. of California/Davis Medical Ctr. (United States)

8:15 to 8:25 pm

Biomedical Imaging and Spectroscopy with Scattered Light
Lev T. Perelman, Harvard Univ./Beth Israel Deaconess Medical Ctr. (United States)

8:25 to 8:35 pm

Frontiers in Functional Optical Coherence Tomography
Zhongping Chen, Univ. of California/Irvine (United States)

8:35 to 8:45 pm

New Instrumentation and Applications of Optical Topography (fNIRS)
Hideaki Koizumi, Hitachi Ltd. (Japan)

8:45 to 8:55 pm

The Extra Microscope
Alberto Diaspro, Istituto Italiano di Tecnologia (Italy)

8:55 to 9:05 pm

Fluorescence Spectroscopy and Microscopy to Image Live Cells
Enrico Gratton, Univ. of California/Irvine (United States)
Neurotechnologies Plenary Session
Date: Sunday 29 January 2017
Time: 3:30 PM - 5:30 PM
Location: Room 3002 (West Level 3)
This new plenary session will highlight the breadth of the exciting advances occurring in the field of neurophotonics and provide a unique forum for communication and networking for leaders and innovators in the neurophotonics community.

SPIE Brain Symposium Chairs


David Boas, Martinos Center, Massachusetts General Hospital, Harvard Medical School (USA)

Rafael Yuste, Columbia Univ. (USA)

3:30-3:35
Welcome and Opening Remarks, David Boas, Martinos Center, Massachusetts General Hospital, Harvard Medical School (USA)

3:35-3:45
Genetically encoded indicators of neuronal activity, Robert Campbell, Univ. of Alberta (Canada)

3:45-3:55
Optical detection of spatial-temporal correlations in whole brain activity, Francesco Pavone, Univ. degli Studi di Firenze (Italy)

3:55-4:05
Two-photon optogenetics with millisecond temporal precision and cellular resolution, Valentina Emiliani, Univ. Paris Descartes (France)

4:05-4:15
A strategy for monitoring synaptic activity across the full dendritic arbor, Peter So, Massachusetts Institute of Technology (USA)

4:15-4:25
3-photon microscopy for deep brain imaging, Chris Xu, Cornell Univ. (USA)

4:25-4:35
Chemical sectioning: high throughput ex-vivo brain imaging, Shaoqun Zeng, Wuhan National Lab. for Optoelectronics (China)

4:35-4:45
Mapping functional connections in the mouse brain: insight to understanding and treating disease, Adam Bauer, Washington Univ. School of Medicine in St Louis (USA)

4:45-4:55
Clinical neuro-monitoring with NIRS-DCS, Maria Angela Franceschini, Athinoula A Martinos Ctr. for Biomedical Imaging (USA)

4:55-5:05
The novel neurotechnologies: impact in science, medicine and society, Rafael Yuste, Columbia Univ. (USA)

5:05-5:15
Opportunities and priorities in neurophotonics: perspectives from the NIH, Edmund Talley, National Institutes of Health (USA)

5:15-5:30
Roundtable Discussion and Q&A

Abstracts and Speaker Biographies
OPTO Plenary Session
Date: Monday 30 January 2017
Time: 8:00 AM - 10:05 AM
Location: Room 3009 (West Level 3)
8:00 am: Welcome and Opening Remarks
Shibin Jiang, AdValue Photonics, Inc. (United States); Jean Emmanuel Broquin IMEP-LAHC (France)

8:00 to 8:05 am
Presentation of 2017 SPIE Technology Achievement Award
Presented by SPIE President to:

Edward Delp III, Purdue Univ. (United States)

The SPIE Technology Achievement Award is given annually to recognize outstanding technical accomplishment in optics, electro-optics, photonic engineering, or imaging. The SPIE Awards Committee has made this recommendation in recognition of his pioneering work in multimedia security including watermarking and device forensics, and for his contributions to image and video compression.

8:05 am: Non-reciprocal photonic gauge potential and non-equilibrium thermal metaphotonics for the control of light and heat

Shanhui Fan, Edward L. Ginzton Lab., Stanford Univ. (United States)

Light, or electromagnetic waves, is a fundamental aspect of the universe. The ability to control light has profound implications for both fundamental science and long-term technological developments. Moreover, since light is one of the major energy and heat carriers, the ability to control light therefore can have important thermodynamic consequences. In this talk I would discuss some of our recent efforts in seeking to control the flow of light with the concept of the photonic gauge potential. I will also discuss efforts in designing ultra-broadband photonic structures for the control of heat flow and for energy harvesting.

Shanhui Fan is a Professor of Electrical Engineering, and the Director of the Edward L. Ginzton Laboratory at the Stanford University. He received his PhD in 1997 in theoretical condensed matter physics from the Massachusetts Institute of Technology (MIT). His research interests are in fundamental studies of solid state and photonic structures and devices, especially photonic crystals, plasmonics, and metamaterials, and applications of these structures in energy and information technology applications. He has published over 380 refereed journal articles that were cited 43,000 times according to Google Scholar. He has given over 280 plenary/keynote/invited talks, and was granted 57 US patents. Prof. Fan received a National Science Foundation Career Award (2002), a David and Lucile Packard Fellowship in Science and Engineering (2003), the National Academy of Sciences Award for Initiative in Research (2007), and the Adolph Lomb Medal from the Optical Society of America (2007). In 2015 he was listed as a Thomson Reuters Highly-Cited Researcher in Physics. He is a Fellow of the IEEE, the American Physical Society, the Optical Society of America, and SPIE.

8:45 am: Quantum dots: genesis, flying q-bits, and energy-efficient nanophotonics

Dieter Bimberg, Institute of Solid State Physics, Technische Univ. Berlin (Germany)

The electronic and optical properties of Semiconductor Quantum Dots are more similar to atoms in a dielectric cage than to those of a semiconductor with energy bands. Record low threshold current density, infinite temperature stability, defect resistance, also in space, and low chirp of semiconductor lasers was predicted and realized. The Gaussian distribution of dot sizes and emission lineshape enables ultrashort optical and electrical pulse generation by mode-locking up to 80 GHz. Optical amplifiers based on QDs show tremendous advantages both for linear and nonlinear applications. Q-bit and entangled photon emission can be easily based on single localized QDs.

Dieter H. Bimberg was the Chair of Applied Physics, Executive Director of the Solid State Physics Institute, founder of the Center of Nanophotonics at TU Berlin. He is member of the German and Russian Academies of Sciences and the US National Academy of Engineering with 50000+ citations of his work.

9:25 am: LiFi: transforming fibre into wireless

Harald Haas, The Univ. of Edinburgh (United Kingdom) and pureLiFi Ltd. (United Kingdom)

We will start by clarifying the differences between visible light communications (VLC) and LiFi. This is followed by the introduction of the key building blocks required to create full LiFi networks. Next we report recent key achievements with respect to component and demonstrator developments underpinning LiFi attocell networks. In this context, the talk showcases how off-the-shelf solar panels can fulfill two functions at the same time: i) energy harvesting and ii) LiFi data detection. We provide modelling results of LiFi attocell networks and address numerous misconceptions such as “LiFi is a line-of-sight technology” or “LiFi does not work when there is strong sunlight.” This talk also addresses the issue of energy efficiency and co-channel interference when there are multiple light sources sending independent data, and closes by summarizing commercialization challenges.

Harald Haas currently holds the Chair of Mobile Communications at the University of Edinburgh, and is founder and Chief Scientific Officer of pureLiFi Ltd as well as the Director of the LiFi Research and Development Center at the University of Edinburgh. His main research interests are in optical wireless communications, hybrid optical wireless and RF communications, spatial modulation, and interference coordination in wireless networks. He first introduced and coined spatial modulation and LiFi. LiFi was listed among the 50 best inventions in TIME Magazine 2011. Prof. Haas was an invited speaker at TED Global 2011, and his talk: "Wireless Data from Every Light Bulb" has been watched online more than 2.4 million times. He gave a second TED Global lecture in 2015 on the use of solar cells as LiFi data detectors and energy harvesters. This has been viewed online more than 1.6 million times.
Nano/Biophotonics Plenary Session
Date: Tuesday 31 January 2017
Time: 10:30 AM - 11:30 AM
Location: Room 3002 (West Level 3)
Welcome and Introduction


Dan Nicolau, McGill Univ. (Canada)


Porous Silicon Nanoparticles as Self-Reporting Drug Delivery Vehicles


Michael J. Sailor, Univ. of California, San Diego (USA)

There is increasing emphasis on biomedical devices that incorporate graceful or sudden degradation into their designs. For in vivo applications, the material components and their degradation products must also be non-toxic. Although bulk silicon is too stable to exhibit significant degradation in the body, nanoscale silicon is readily degradable and quite biocompatible. This presentation will discuss the chemistry and photochemistry of luminescent porous silicon, with emphasis on the self-destruction and reconstruction processes that can be harnessed for various in vitro and in vivo imaging and drug delivery tasks.

Michael J. Sailor is Distinguished Professor of Chemistry and Biochemistry at the University of California, San Diego, and he holds Affiliate Appointments in the Bioengineering, the Nanoengineering, and the Materials Science and Engineering programs at UCSD. Trained as a chemist, Sailor received his training at Harvey Mudd College (B.S.) and Northwestern University (Ph.D.). He is a Fellow of the American Association for the Advancement of Science, the U.S. National Academy of Inventors, and the Royal Society of Chemistry.
LASE Plenary Session
Date: Wednesday 1 February 2017
Time: 10:20 AM - 12:30 PM
Location: South Exhibit Level, Room 103
10:20 am: Welcome and Opening Remarks
Reinhart Poprawe, Fraunhofer-Institut für Lasertechnik (Germany) and Koji Sugioka, RIKEN (Japan)

10:25 am: Announcement of the 3D Printing, Fabrication, and Manufacturing Best Paper Award
Henry Helvajian, The Aerospace Corp. (United States)

10:30 to 11:10 am:
Gravitational Wave Astronomy: News from the Dark Side of the Universe
Prof. Dr. Karsten Danzmann
Director at the Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Hannover, Head of the division Laser Interferometry and Gravitational Wave Astronomy, and Director of the Institute for Gravitational Physics at the Leibniz Univ. Hannover (Germany)

Abstract: So far, we have only been able to look at the universe and observe it with electromagnetic waves. But most of the universe is dark and will never be observable with light. Since September 2015 we can use a new sense and from now on we will be able to listen to the universe using gravitational waves with detectors on the ground and soon in deep space.

Biography: Karsten Danzmann was born in 1955 and obtained his PhD in 1980. He is working on all aspects of laser interferometric gravitational wave detection on the ground and in space and is a professor of physics at Leibniz Universität Hannover, Director at the Max Planck Institute for Gravitational Physics, and Director of the Institute for Gravitational Physics at Leibniz Universität Hannover. He is the Lead Scientist of the German-British GEO600 gravitational wave detector, Co-PI of the LISA Pathfinder space mission and Consortium Lead of the eLISA mission.

11:10 to 11:50 am:
Printing Hybrid Electronics by Laser Direct-Write
Dr. Alberto Piqué
Branch Head at the U.S. Naval Research Lab. (United States)

Abstract: The use of laser direct-write (LDW) techniques for printing functional materials for a wide-range of applications is growing as additive manufacturing or AM becomes more established. With LDW, precise control of a wide range of processing steps — from subtractive to additive — is possible over a wide range of scales with an extensive materials palette. These non-lithographic processes constitute some of the earliest demonstrations of 3D printing or AM at the microscale. This talk will review the current status of micro-fabrication processes based on LDW, such as laser-induced forward transfer or LIFT, and their use to fabricate “hybrid” structures comprising both printed and embedded electronic components. These examples will illustrate the role that LDW is poised to play in the additive micro-fabrication of hybrid circuits for the development of the next generation of 3D printed electronics.

This work was funded by the Office of Naval Research (ONR) through the Naval Research Laboratory Basic Research Program.

Biography: Dr. Alberto Piqué is the Head of the Materials and Systems Branch in the Materials Science Division at the Naval Research Laboratory. Dr. Piqué and his group have pioneered the use of laser-based direct-write techniques for the rapid prototyping of electronic, sensor and micro-power generation devices. He is a Fellow of SPIE and APS, and to date his research has resulted in over 200 scientific publications and 21 patents.

11:50 am to 12:30 pm:
Development of 250W EUV Light Source for HVM Lithography
Dr. Hakaru Mizoguchi
CTO and Executive VP of Gigaphoton Inc. (Japan)

Additional Authors: H. Nakarai, T. Abe, K. M. Nowak, Y. Kawasuji, H. Tanaka, Y. Watanabe, T. Hori, T. Kodama, Y. Shiraishi, T. Yanagida, G. Soumagne, T. Yamada, T. Yamazaki, S. Okazaki and T. Saitou, Gigaphoton Inc. (Japan)

Abstract: We have been developing CO2-Sn-LPP EUV light source for HVM EUVL. We have reported engineering data from our resent test such around 118W average clean power, CE=3.7%, with 100kHz operation and other data 1). We have already finished preparation of higher average power CO2 laser more than 20kW at output power cooperate with Mitsubishi electric cooperation 2). Further improvements are underway, we will report the latest data. Also we will report the latest data of Pilot 250W EUV source system.
1) Hakaru Mizoguchi, et. al, Proc. SPIE 9048, (2014) [9048-12]
2) Yoichi Tanino et.al, EUV Symposium 2013, (Oct.6-10.2013, Toyama)

Biography: Hakaru Mizoguchi was appointed Vice President and CTO in April 2012. After joining Komatsu in 1982, he was fully involved in development of the CO2 laser. For two years he worked on research of excimer laser technology as a guest researcher at the Max Planck Research Institute in Göttingen, Germany. Then he obtained a doctorate from Kyushu University, and in 1998 was appointed General Manager of Laser Research Department, Research Center, where he played a central role in research on excimer lasers in Japan. Mizoguchi has been a part of Gigaphoton’s management since its founding, serving as General Manager of the Research Division, General Manager of the Development Division, General Manager of Customer Support Division, and Director and CTO. He has promoted research and development of the KrF, ArF, and F2 laser light sources and of EUV light sources for photolithography. He will continue to promote the development of Gigaphoton’s leading-edge technologies. Member of the SPIE, the Laser Society of Japan, and the Japan Society of Applied Physics.
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