The Moscone Center
San Francisco, California, United States
2 - 7 February 2019
Plenary Events
BIOS Hot Topics
Date: Saturday 2 February 2019
Time: 7:00 PM - 9:00 PM
Location: Room 206/214 (South Level Two)
7:00 PM - 7:05 PM: Welcome and Opening Remarks

BIOS 2019 Symposium Chair
James Fujimoto, Massachusetts Institute of Technology (United States)

BIOS 2019 Symposium Chair
R. Rox Anderson, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard School of Medicine (United States)

7:05 PM - 7:10 PM: Presentation of 2019 Biophotonics Technology Innovator Award
Presented by SPIE President to Stephen Boppart, Univ. of Illinois at Urbana-Champagne (United States)

The Biophotonics Technology Innovator Award is presented annually for extraordinary achievements in biophotonics technology development that show strong promise or potential impact in Biology, Medicine, and Biomedical Optics. The award is given to Stephen Boppart in recognition of the development of novel technology in computational optical coherence tomography and its applications to basic and clinical sciences. His work will be represented in the following three presentations scheduled in BiOS.

Slide-free molecular histopathology using simultaneous label-free auto-fluorescence multi-harmonic (SLAM) microscopy [10882-73]
Real-time label-free multimodal multiphoton imaging for assessing the intraoperative tumor microenvironment [10862-1]
Coherent control of an opsin in living brain tissue [10888-14]

7:10 PM - 7:15 PM: Presentation of the SPIE-Franz Hillenkamp Postdoctoral Fellowship in Problem-Driven Biophotonics and Biomedical Optics

7:15 PM - 7:20 PM: Presentation of 2019 Britton Chance Biomedical Optics Award
Presented by SPIE President to Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)

The Britton Chance Biomedical Optics Award is presented annually in recognition of outstanding lifetime contributions to the field of biomedical optics through the development of innovative, high impact technologies. The award particularly honors pioneering contributions to optical methods and devices that have facilitated advancements in biology or medicine. The SPIE Awards Committee has made this recommendation in recognition of transformative advancements in optical and molecular imaging that have pushed the boundaries of cancer care and treatment and the clinical translation of technologies to improve patient care.

7:20 PM - 7:40 PM: Power of Light to See and Treat Cancer

Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)

7:40 PM to 7:45 PM: Hot Topics Facilitator Remarks

Sergio Fantini, Tufts Univ. (United States)

7:45 PM - 7:55 PM: New Frontiers in Near-infrared Spectroscopy

Clare Elwell, Univ. College London (United Kingdom)

7:55 PM - 8:05 PM: Spectroscopic Cancer Detection

Zhiwei Huang, National Univ. of Singapore (Singapore)

8:05 PM - 8:15 PM: Multispectral Optoacoustic Tomography

Daniel Razansky, Univ. of Zurich and ETH Zurich (Switzerland)

8:15 PM - 8:25 PM: The Clogged Brain Drain and Other Misadventures in Aging as Seen Through Translational Biomedical Optics

Eva Sevick, Univ. of Texas Houston (United States)

8:25 PM - 8:35 PM: Plasmonic Patch: A Universal Fluorescence Enhancer

Srikanth Singamaneni, Washington Univ. at St. Louis (United States)

8:35 PM - 8:45 PM: Precision Surgery by Targeted Molecular Imaging

Alexander Vahrmeijer, Leiden Univ. Medical Ctr. (The Netherlands)

8:45 PM - 8:55 PM: Recent Advances in Multiphoton Imaging

Chris Xu Cornell Univ. (United States)

8:55 PM - 9:05 PM: Extending Optical Coherence Tomography Toward Multiple-Contrast Imaging

Yoshiaki Yasuno, Univ. of Tsukuba (Japan)
Neurotechnologies Plenary Session
Date: Sunday 3 February 2019
Time: 3:30 PM - 5:30 PM
Location: Room 206/214 (South Level Two)
Initiated in 2017, this session will highlight the breadth of exciting advances occurring in the field of neurophotonics and provide a unique forum for communication and networking for leaders and innovators in the neurophotonics community.

SPIE Brain Symposium Chairs

David Boas, Boston Univ. (United States)

Elizabeth Hillman, Columbia Univ. (United States)


The Miniscope project: developing imaging technology via an open-source platform
Denise Cai, Icahn School of Medicine at Mount Sinai (USA)

Extending multiphoton microscopy to 3D brain imaging in freely moving mice
Emily Gibson, Univ. of Colorado Denver (USA)

Towards objective assessment of surgical skills with functional near-infrared spectroscopy (fNIRS)
Xavier Intes, Rensselaer Polytechnic Institute (USA)

Human brain interferometers for better blood flow monitoring
Vivek Srinivasan, Univ. of California, Davis (USA)

Watching the brain in action: creating tools for functional analysis of neural circuitry
Lin Tian, Univ. of California, Davis (USA)

Quantitative imaging of large cleared samples with light sheet theta microscopy
Raju Tomer, Columbia Univ. (USA)

Panel Discussion, Moderated by Edmund Talley, National Institutes of Health (USA)

Abstracts and Speaker Biographies
BiOS Sunday Plenary Session
Date: Sunday 3 February 2019
Time: 7:15 PM - 8:00 PM
Location: Room 206/214 (South Level Two)
Welcome and Introduction

Jim Oschmann, 2019 SPIE President

Talk by 2018 Nobel Prize Winner in Physics

Donna Strickland, Univ. of Waterloo. (Canada)

Prize wording: The Nobel Prize in Physics 2018 was awarded “for groundbreaking inventions in the field of laser physics” with one half to Arthur Ashkin “for the optical tweezers and their application to biological systems” and the other half jointly to Gérard Mourou and Donna Strickland “for their method of generating high-intensity, ultra-short optical pulses”. Their inventions have revolutionised laser physics. Extremely small objects and incredibly rapid processes are now being seen in a new light. Advanced precision instruments are opening up unexplored areas of research and a multitude of industrial and medical applications.

Biography: Dr. Strickland is a Professor at the Univ. of Waterloo and is the third woman to receive a Nobel Prize in Physics and the first in 55 years. She received her undergraduate degree at McMaster Univ. (Canada) and her MS and PhD from the Univ. of Rochester. Her work has been focused in intense laser-matter interactions, nonlinear optics, short-pulse intense laser systems, chirped pulse amplification, and ultrafast optics. Dr. Strickland has received an Alfred P. Sloan Research Fellowship, Premier's Research Excellence Award, Cottrell Scholars Award from Research Corp., and is a Fellow of the Optical Society.
OPTO Plenary Session
Date: Monday 4 February 2019
Time: 8:00 AM - 10:05 AM
Location: Room 207/215 (South Level Two)
8:00 AM - 8:05 AM: Welcome and Opening Remarks
Connie J. Chang-Hasnain, Univ. of California, Berkeley (United States); Graham T. Reed Optoelectronics Research Ctr. (United Kingdom)

8:05 AM - 8:45 AM: Hyperscale Data Center Applications of Optoelectronics

Katharine Schmidtke, Facebook (United States)

From subsea fiber cables to short-reach switch interconnects, optoelectronics is a key technology for hyperscale data center networks. As performance requirements increase, photonics moves deeper into the network replacing copper for shorter distances. The next move for photonics is to distances of less than 3m for in-rack applications. This talk will describe how the scale of data-bandwidth growth has challenged what is possible with traditional networks and where the next opportunities for innovation lie.

Katharine Schmidtke is responsible for Optical Technology Strategy at Facebook. She has more than 20 years experience in the Opto-Electronics industry, including positions at Finisar, JDSU, and New Focus. She has a Ph.D. in non-linear optics from Southampton University in the UK and completed post-doctoral research at Stanford University.

8:45 AM - 9:25 AM: Two Decades of Progress for Photonic Crystals: From the Realization of Complete 3D Crystals to the State of the Art for Society 5.0

Susumu Noda, Kyoto Univ. Graduate School of Engineering (Japan)

Almost two decades have passed since the realization of complete 3D photonic crystals at optical wavelengths. During these years, the manipulation of photons by photonic crystals has progressed tremendously. For example, the concept of confining photons to a very small modal volume has been established and nanocavity Q-factors have exceeded ten million, enabling platforms for strong light-matter interaction and quantum information processing. Photonic crystals allow even a broad-area manipulation of photons, by which semiconductor lasers with a very bright, narrow-divergence beam and various functionalities including 2D beam steering have been realized. Such lasers are promising for applications in light-detection and ranging (LiDAR) and direct material processing, which are important for the forthcoming Society 5.0. Photonic crystals also enable thermal emission control, by which the issues of conventional thermal emission devices such as their extremely broad emission spectra and slow response speed have been fixed, and a renovation of thermal emission devices has been achieved. In this plenary talk, we will review such progress of photonic crystals including their social applications.

Susumu Noda received B.S., M.S., and Ph.D. degrees from Kyoto University, Japan, in 1982, 1984, and 1991, respectively, all in electronics, and an Honorary degree from Gent University, Gent, Belgium, in 2006. From 1984 to 1988, he was with the Mitsubishi Electric Corporation, and he joined Kyoto University in 1988. He is currently a full Professor in the Department of Electronic Science and Engineering and the Director of the Photonics and Electronics Science and Engineering Center at Kyoto University. He has received various awards, including the Optical Society of America Joseph Fraunhofer Award (2006), the IEEE Nanotechnology Pioneer Award (2009), the Medal with Purple Ribbon (2014), and the Japan Society of Applied Physics Outstanding Achievement Award (2015).

9:25 AM - 10:05 AM: Deep Learning Optics

Aydogan Ozcan, California NanoSystems Institute (United States) and Univ. of California, Los Angeles (United States)

In the first part of this presentation, we will discuss recently emerging applications of the state-of-art deep learning methods on optical microscopy and microscopic image reconstruction, which enable image enhancement and new transformations among different modalities of microscopic imaging, driven entirely by image data. In this second part, we introduce a physical mechanism to perform machine learning by demonstrating a Diffractive Deep Neural Network architecture that can all-optically implement various functions following the deep learning-based design of passive layers that work collectively. We created 3D-printed diffractive networks that implement classification of images of handwritten digits and fashion products as well as the function of an imaging lens at terahertz spectrum. This passive diffractive network can perform, at the speed of light, various complex functions that computer-based neural networks can implement, and will find applications in all-optical image analysis, feature detection and object classification, also enabling new camera designs and optical components that perform unique tasks using diffractive neural networks.

Aydogan Ozcan is the Chancellor’s Professor at UCLA and an HHMI Professor with the Howard Hughes Medical Institute, leading the Bio- and Nano-Photonics Laboratory at UCLA and is also the Associate Director of the California NanoSystems Institute. Dr. Ozcan holds 37 issued patents and <20 pending patent applications and is also the author of one book and the co-author of <500 peer-reviewed publications in major scientific journals and conferences. Dr. Ozcan is the founder and a member of the Board of Directors of Lucendi Inc. and Holomic/Cellmic LLC, which was named a Technology Pioneer by The World Economic Forum in 2015. Dr. Ozcan is a Fellow of SPIE, The Optical Society (OSA), the American Institute for Medical and Biological Engineering (AIMBE), the Institute of Electrical and Electronics Engineers (IEEE), the Royal Society of Chemistry (RSC), and the Guggenheim Foundation, and he has received major awards including the Presidential Early Career Award for Scientists and Engineers, International Commission for Optics Prize, Biophotonics Technology Innovator Award, Rahmi M. Koc Science Medal, International Photonics Society Early Career Achievement Award, Army Young Investigator Award, NSF CAREER Award, NIH Director’s New Innovator Award, Navy Young Investigator Award, IEEE Photonics Society Young Investigator Award and Distinguished Lecturer Award, National Geographic Emerging Explorer Award, National Academy of Engineering The Grainger Foundation Frontiers of Engineering Award and MIT’s TR35 Award for his seminal contributions to computational imaging, sensing and diagnostics.
LASE Plenary Session
Date: Monday 4 February 2019
Time: 3:30 PM - 5:40 PM
Location: Room 207/215 (South Level Two)
3:30 PM - 3:35 PM: Welcome and Opening Remarks
Beat Neuenschwander, Berner Fachhochschule Technik und Informatik (Switzerland) and Xianfan Xu, Purdue Univ. (United States)

3:35 PM - 3:40 PM: Announcement of the 3D Printing, Fabrication, and Manufacturing Best Paper Award
Henry Helvajian, The Aerospace Corp. (United States)

3:40 PM - 4:20 PM: Cassini’s Grand Finale: Going Out in a Blaze of Glory

Earl H. Maize, Jet Propulsion Lab. (United States)

The Cassini spacecraft ended its 20-year voyage of discovery with a fiery plunge into Saturn’s atmosphere on Sept. 15, 2017. We will discuss the engineering and scientific rationale for the mission’s final scenario and some of the complexities of an entirely new mission for an aging spacecraft. We will also present highlights from the many amazing findings from the spacecraft’s 13 years of exploration in the Saturn system.

Dr. Earl H. Maize is the Program Manager of the NASA Cassini Mission, Jet Propulsion Lab., a mission that began exploring the Saturn system in 2004 and recently concluded with a spectacular plunge into Saturn’s atmosphere in September 2017. He has worked at the Jet Propulsion Laboratory for the past 34 years. He previously worked on the Galileo mission to Jupiter and held management positions in System Engineering and Guidance, Navigation and Control.

4:20 PM - 5:00 PM: Quarter Century Development of Laser Peening and Recent Strides toward Expansion of Applications

Yuji Sano, Japan Science and Technology Agency (Japan)

Underwater laser ablation with nanoseconds lasers generates high-pressure plasma exceeding GPa, and can be used as a hammer to forge the surface of most metals. This technology is known as laser peening (LP) and has been used in aeronautical and nuclear industries since the late 1990s. Most recently, we have developed a novel LP process without water by using a femtosecond laser, which extends the application to integrated systems with mechanics and electronics incompatible with aqueous environment, and even to components in space. Various applications would be realized by enhancing usability through miniaturization and simplification. In this context, we have developed ultra-compact handheld microchip lasers with passive Q-switch generating sub-nanosecond pulses, which paves the way to a wide range of new applications beyond the horizons posed by current laser systems.

Dr. Yuji Sano is a Program Manager (PM) of ImPACT (Impulsing Paradigm Change through Disruptive Technologies program) under the cabinet office of the Japanese government. He is managing R&D activities for laser wakefield acceleration of electrons and high-power solid-state pulsed lasers. Until designated as the PM in 2014, he had served Toshiba Corporation and developed laser applications especially laser peening since 1994. From 2008 to 2014, he concurrently served as a Program Officer of Photon Frontier Network supported by the government.

5:00 PM - 5:40 PM: High Power Laser Diodes: Improvements in Power, Efficiency, and Brilliance

Günther Tränkle, Ferdinand-Braun-Institut (Germany)

GaAs-based high-power diode lasers are the world’s most efficient light sources and generate the optical energy for the largest and fastest growing laser market: material processing. The performance of these key components is improving dramatically, driven by advances in material quality, process technology and design capability. FBH’s studies to improve the understanding of the physics and material properties that limit performance are an essential part of this development. An overview will be presented, detailing how power, efficiency and beam quality have been improved over the past 20 years, and showing the path to further performance scaling.

Prof. Dr. Günther Tränkle received a PhD in physics in 1988 (Univ. Stuttgart). From 1988-94 he was a Postdoc at TU München. In 1995, he was Department Head at Fraunhofer-IAF in Freiburg, and in 1996, he became Director of Ferdinand-Braun-Institute in Berlin. Since 2002 he is Full Professor at TU Berlin for microwaves and optoelectronics. Additionally, in 2013-17 he was Acting Director of Leibniz-Institute for Crystal Growth in Berlin.
Nano/Biophotonics Plenary Session
Date: Tuesday 5 February 2019
Time: 10:30 AM - 11:30 AM
Location: Room 207 (South Level Two)
Welcome and Introduction

Dan Nicolau, McGill Univ. (Canada)

Engineering with Biomolecular Motors

Henry Hess, Columbia Univ. (United States)

Motor proteins, including kinesin, can serve as biological components in engineered nanosystems. A proof-of-principle application is a "smart dust" biosensor for the remote detection of biological and chemical agents. The development of this system requires the integration of a diverse set of technologies, illustrates the complexity of biophysical mechanisms, and enables the formulation of general principles for nanoscale engineering. For example, our most recent work created a molecular system that is capable of dynamically assembling and disassembling its building blocks while retaining its functionality, and demonstrates the possibility of self-healing and adaptation. Optical techniques are a key tool to interrogate and interact with these nanosystems as they enable non-destructive measurements with nanometer precision as well as the control of chemical events at the nanoscale. The presentation will highlight the important contributions of photonics to the study of active nanosystems.

Dr. Henry Hess is a Professor of Biomedical Engineering at Columbia University in the City of New York and the Editor-in-Chief of the IEEE Transactions on NanoBioscience. He received a Diploma (M.S.) in Physics from the Technical University Berlin (Germany) in 1996 and the Dr. rer. nat. in Physics from the Free University Berlin (Germany) in 1999. After appointments as Postdoctoral Scientist and Research Assistant Professor at the Department of Bioengineering at the University of Washington, he joined the Department of Materials Science and Engineering at the University of Florida in 2005 as Assistant Professor. Since 2009, he has been teaching and researching at Columbia University.
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